![]() Normal peripheral blood-derived monocyte-differentiated macrophages expressed TRAIL R2 (P < 0.01), but not TRAIL or the other TRAIL receptors. In contrast, RA SF macrophages expressed TRAIL R3, a decoy receptor (P < 0.01 versus isotype control), but not TRAIL, or TRAIL R1, R2, or R4. By flow cytometry, neither TRAIL nor its cognate receptors was detectable on RA SF lymphocytes or RA synovial fibroblasts. The ability of adenoviral-mediated delivery of TRAIL to induce macrophage or RA synovial fibroblast apoptosis was examined by flow cytometry. The expression of TRAIL and TRAIL receptors on RA SF lymphocytes and monocyte/macrophages, normal macrophages, and RA synovial fibroblasts was examined by flow cytometry with previously characterized monoclonal antibodies. To characterize the expression pattern of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate receptors (TRAIL R1, R2, R3, and R4) on rheumatoid arthritis (RA) synovial fluid (SF) lymphocytes and monocyte/macrophages and on cultured RA synovial fibroblasts. Korn JH, Torres D, Downie E (1984) Clonal heterogeneity in the fibroblast response to mononuclear cell derived mediators.Objective. Vuoric E, Einola S, Hakkarainen S, Penttinen R (1982) Synthesis of underpolymerized hyaluronic acid by fibroblasts cultured from rheumatoid and non-rheumatoid synovitis. Regulation of glycosaminoglycan metabolism by lymphocyte (CTAP-I) and platelet (CTAP-III) growth factors. Proc Soc Exp Biol Med 177:205–210Ĭastor CW, Bignall MC, Hossler PA, Roberts DJ (1981) Connective tissue activation XXI. ![]() Hamerman D, Wood DD (1984) Interleukin 1 enhances synovial cell hyaluronate synthesis. Saarni H, Tammi M (1977) A rapid method for separation and assay of radiolabeled mucopolysaccharides from cell culture medium. J Immunol Methods 26:193–196Ĭhen TR (1977) In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Ann Rheum Dis 43:313–319ĭeJong MCJM (1979) Esterase staining of human peripheral blood mononuclear cells. Arthritis Rheum 25:1469–1476Ĭlarris BJ, Fraser JRE, Muirden KD, Malcolm CP, Holmes MWA, Rogers K (1984) Stimulation of glycosaminoglycan production and lysosomal activity of human synovial cells in culture by low environmental pH. J Rheumatol 10:861–871īetts WH, Cleland LG (1982) Effect of metal chelators and anti-inflammatory drugs on the degradation of hyaluronic acid. Golds EE, Santer V, Killackey J, Roughley PJ (1983) Mononuclear cell factors stimulate the concomitant secretion of distinct latent proteoglycan, gelatin and collagen-degrading enzymes from human skin fibroblasts and synovial cells. Hamilton JA, Clarris BJ, Fraser JRE, Niall MC (1985) Peripheral blood mononuclear cells stimulate prostacyclin levels of human synovial fibroblast-like cells. Ann NY Acad Sci 256:304–317Ĭlarris BJ, Hamilton JA (1985) Peripheral blood mononuclear cells stimulate N-acetyl-β-glucosaminidase levels of human fibroblast-like cells. J Rheumatol (Suppl 11) 10:55–60Ĭastor CW (1975) Synovial cell activation induced by a polypeptide mediator. J Rheumatol 10:872–880Ĭastor CW (1983) Regulation of connective tissue metabolism by autacoid mediators. Studies on the mechanisms of action of synovial activator activities. Hamilton JA (1983) Synovial cell activation. Wood DD, Ihrie EJ, Dinarello CA, Cohen PL (1983) Isolation of an interleukin 1-like factor from human joint effusions. Krane SM (1981) Aspects of the cell biology of the rheumatoid synovial lesions. Pulkki K, Vuorio E, Jalava S (1983) The effect of rheumatoid synovial fluid macrophages on DNA, glycosaminoglycan and collagen synthesis by synovial fibroblasts. Schumacher HR, Kitridou RC (1972) Synovitis of recent onset: a clinicopathologic study during the first month of the disease. Scand J Clin Lab Invest 37 (Suppl 149):1–72 ![]() Vuorio E (1977) Rheumatoid disease in cultured synovial cells. Snyderman R, McCarty GA (1978) The role of macrophage in the rheumatic diseases. Ziff M (1974) Relation of cellular infiltration of rheumatoid synovial membrane to its immune response.
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